Since its foundation, MEDSEA has developed several important collaborations with private entities (Edilana, Castalia, IED) and Public Authorities (Municipalities, marine protected areas, parks authorities, governments, international institutions) at regional, national and international level in the Mediterranean basin and beyond (Sao Tome and Principe). 

It has developed projects on sustainable tourism, coastal zone management, life cycle assessment, coastal waste management, protection and conservation of marine ecosystem areas and wetlands and for the organization of training courses and communication events.